|Sung-Cheng "Henry" Huang
Molecular & Medical Pharmacology
We study the delivery, transport, metabolism and receptor binding of labeled compounds and drugs in local tissue regions in vivo, using the methodologies of quantitative PET, tracer kinetics and modeling. Tracer kinetic models are formulated and validated based on experimental biochemical information. Based on the validated models, practical study procedures and reliable estimation techniques are developed to obtain quantitative biological information in vivo in humans. Major emphasis is on the understanding of basic mechanisms related to the uptake, clearance and metabolism of labeled compounds under various conditions. Biological parameters studied include blood perfusion, glucose utilization rate, oxygen consumption rate, dopamine D2 receptor density, and fluoroDOPA decarboxylation rate.
Huang SC, Yu DC, Barrio JR, Grafton S, Melega WP, Hoffman JM, Satyamurthy N, Mazziotta JC, Phelps ME. (1991) Kinetics and modeling of 6-[F-18] fluoro-L-DOPA in human positron emission tomographic studies. J Cereb Blood Flow Metab 11: 898-913.
Feng, Dagan; Li, Xianjin; Huang, Sung-Cheng (1996) A new double modeling approach for dynamic cardiac PET studies using noise and spillover contaminated LV measurements. (positron emission tomography; left ventricle). IEEE Transactions on Biomedical Engineering 43, n3: 319.
Yang, J.; Lin, K.P.; Huang, S.C.; Wolfenden, P.; Dahlbom, M.; Hoh, C.K.; Phelps, M.E.; Czernin, J. (1996) A new axial smoothing method based on elastic mapping. IEEE Transactions on Nuclear Science 43, n6: 3355.
Yang, J.; Huang, S.C.; Mega, M.; Lin, K.P.; Toga, A.W.; Small, G.W.; Phelps, M.E. (1996) Investigation of partial volume correction methods for brain FDG PET studies. (fluorodeoxyglucose; positron emission tomography). IEEE Transactions on Nuclear Science 43, n6: 3322.
Zhou, Yun; Huang, S.C.; Cloughesy, T.; Hoh, C.K.; Black, K.; Phelps, M.E (1997) A modeling-based factor extraction method for determining spatial heterogeneity of a Ga-68 EDTA kinetics in brain tumors.(Selected Papers from the 1996 Medical Imaging Conference). IEEE Transactions on Nuclear Science 44, n6: 2522.
Chinn, Garry; Huang, Sung-Cheng (1997) A general class of preconditioners for statistical iterative reconstruction of emission computed tomography. IEEE Transactions on Medical Imaging 16, n1: 1.
Tai, Yuan-Chuan; Lin, Kang Ping; Hoh, Carl K.; Huang, S.C. Henry; Hoffman, Edward (1997) Utilization of 3-D elastic transformation in the registration of chest x-ray CT and whole body PET. IEEE Transactions on Nuclear Science 44, n4: 1606.
Chen, Kewei; Lawson, Michael; Reiman, Eric; Cooper, Alan; Feng, Dagan; Huang, Sung-Cheng, Bandy, Daniel; Ho, Dino; Yun, Lang-sheng; Palant, Anita (1998) Generalized linear least squares method for fast generation of myocardial blood flow parametric images with N-13 ammonia PET. (positron emission tomography. IEEE Transactions on Medical Imaging 17, n2: 236.
Huang, Sung-Cheng; Zhou, Yun (1998) Spatially-coordinated regression for image-wise model fitting to dynamic PET data for generating parametric images.(Selected Papers from the 1997 Nuclear Science Symposium & Medical Imaging Conference). IEEE Transactions on Nuclear Science 45, n3: 1194.
Farquhar, T.H.; Chinn, G.; Hoh, C.K.; Huang, S.-C.; Hoffman, E.J. A (1998) nonlinear, image domain filtering method for cardiac PET images. (positron emission tomography)(Selected Papers from the 1997 Medical Imaging Conference (MIC)) IEEE Transactions on Nuclear. IEEE Transactions on Nuclear Science 45, n4: 2073.