KIS stands for Kinetic Imaging System. It is a fully integrated software system to assist the learning, planning, design, and data analysis of mouse microPET studies. Through computer simulation and animation of tracer kinetics in all tissue organs of a whole animal (based on a realistic 3D mouse atlas), KIS allows users to learn and to evaluate conveniently a multiple of biological, chemical, and experimental factors that could affect the mouse microPET images. Its main module, in fact, allows users to perform "virtual" mouse microPET studies quickly and conveniently without using a real animal. The system serves multiple functions-education, virtual experimentation, experimental design, and image analysis of experimental data. It consists of 4 main modules-"Dictionary", "Virtual Experimentation Lab (Regional Tissue Kinetics and Integrated Whole Body Kinetics)", "Image Analysis", and "Model Fitting Lab".

KIS is coded completely in Java to give it the important features of platform-independence, low software maintenance and long product life. It can be run either through the Web from a server or on a stand-alone station. With KIS, radio-tracer characteristics, administration method, dose level, imaging sequence, image reconstruction (e.g., resolution vs. noise tradeoff) can be evaluated before one actually performs a mouse microPET experiment. Various kinetic data analysis procedures (including model fitting) can be examined to ensure reliable biological information can be obtained. KIS is designed for biology and pharmaceutical scientists in a way that make learning and applying tracer kinetics and pharmacokinetics to interesting problems fun and easy to do.

Henry Huang
David Truong

KIS is owned by UCLA Molecular & Medical Pharmacology Department and is protected by copyright laws and international copyright treaty provisions, as well as other intellectual property laws and treaties. Therefore, you must treat KIS like any other copyrighted material. You may not use or copy KIS for any other purpose than what is described in this Agreement.